Tenecteplase tnkase a d d r e s s o g r a p h treatment regimen. Fabrazyme helps people with fabry disease by replacing a missing enzyme. Alteplase is an enzyme that has the property of fibrinenhanced conversion of plasminogen. Alteplase is produced by recombinant dna technique using a chinese hamster ovary cellline. If you have questions about this medicine talk to your doctor, pharmacist, or health care provider. Alteplase package insert pdf keyword after analyzing the system lists the list of keywords related and the list of websites with related content, in addition you can see which keywords most interested customers on the this website. Metalyse is not for use in patients with a known hypersensitivity to the active substance, tenecteplase, gentamicin a trace residue from the manufacturing process or any of the excipients. Highlights of prescribing information these highlights do not include all the information needed to use cubicin safely and effectively. Activase alteplase is an enzyme, which works to break up and dissolve blood clots that can block arteries, used in the treatment of an acute heart attack or pulmonary embolism. Each kit contains one 50 mg vial of tnkase, one 10 ml vial of preservativefree sterile water for injection, usp, one bd 10 ml syringe with twinpak dual cannula device, three alcohol prep pads, and package insert containing full prescribing information. This pdfoverlay package provides a simple interface to overlay text on to an. Tenecteplase is used to dissolve blood clots that have formed in the blood vessels of the heart and seriously lessen the flow of blood in the heart. The activase package insert you have selected will take you away from this site to one that is not owned or controlled by genentech, inc. Lactation there are no data on presence of activase package insert in human milk, effects on inssrt infant, or on milk production.
Not only is tenecteplase a cheaper and more convenient thrombolytic agent than alteplase, but new research suggests it also leads to better outcomes in stroke patients selected for endovascular thrombectomy. Tnkase fda prescribing information, side effects and uses. Reteplase is used to improve heart function and prevent congestive heart failure or death in people who. N2piperidinylmethyl2, 5bis 2,2,2trifluoroethoxy benzamide acetate, belongs to the benzamide class of antiarrhythmic drugs and is structurally related to lignocaine and procainamide. Frequently asked questions about activase alteplase in. Cathflo activase alteplase is indicated for restoration of function to clotted central venous access devises as assessed by the inability to withdraw blood. Medication discarded in this manner may contaminate the environment. Do not freeze medicines unless required by package insert. What should i discuss with my health care provider before i receive tenecteplase tnkase. Can open a pdf file and work as a simple pdf reader. Acls drugs, cardioversion, defibrillation and pacing ace inhibitors angiotensinconverting enzyme inhibitors enalapril captopril lisinopril ramipril indications ace inhibitors reduce mortality and improve lv dysfunction in postami patients. Clinical pharmacology general tenecteplase is a modified form of human tissue plasminogen activator tpa that binds to fibrin. Treatment should be initiated as soon as possible after the onset of ami symptoms. Singleuse vial lytic thrombolytic cathflo activase.
Tenecteplase intravenous route description and brand names. Alteplase is an injectable drug, given directly into a vein, that is used to treat conditions caused by arterial blood clots including heart attacks, strokes, chest pain at rest unstable angina, blood clots in the lungs pulmonary thrombosis or embolus, and other less common conditions involving blood clots. Tenecteplase superior to alteplase for stroke thrombolysis. Plavix has been evaluated for safety in more than 54,000 patients, including over 21,000 patients treated for one year or more. Using cathflo activase in patients with infected catheters may release a localized infection into the systemic circulation. Sep 06, 2019 cathflo activase alteplase for injection is a sterile, white to pale yellow, lyophilized powder for intracatheter instillation for restoration of function to central venous access devices following reconstitution with sterile water for injection, usp. The ageadjusted death rate in 1991 was 186 per 100,000. By continuing to browse this site you are agreeing to our use of cookies. Use urokinase or retaplase that has been aliquotted by your pharmacy. Inclusion and exclusion criteria for iv alteplase tissue. Reteplase injection retavase is a nonglycosylated deletion mutein of tissue plasminogen activator tpa, produced by recombinant dna technology in e. Tenecteplase, tnktpa injection medication guide note. The specific activity of alteplase inhouse reference material is 580,000 iumg. Tenecteplase ten neck te place is used to dissolve blood clots that form in certain blood vessels.
Inside the alteplase package, you should find one vial of 100 ml of preservativefree sterile water for injection, one vial of 100 mg of alteplase, and the transfer device. Reteplase side effects, dosage, interactions everyday health. Remove the protective cap from the other end of the transfer device. An instruction booklet for the preparation of drug suspension for injection is. Intended use the qms amikacin assay is intended for the quantitative determination of amikacin in human serum or plasma on automated clinical chemistry analyzers. Cathflo activase should be used with caution in the presence of known or suspected infection in the catheter. Reliability of assay results cannot be guaranteed if there are any deviations from the instructions in this package insert. Precautions the decision to treat a patient with acute myocardial infarction with metalyse metalyse metalyse. It is a sterile, purified glycoprotein of 527 amino acids. Cathflo activase package insert keyword found websites. The clinically important adverse reactions observed in trials comparing plavix plus aspirin to placebo plus aspirin and trials comparing plavix alone to aspirin alone are discussed below.
With the vial sitting on a flat surface, insert the tip of the syringe into the adapter opening. Prescribing and administration guide for intraarterial. Lift the package cover away from the vial adapter and discard the cover. Activase is an enzyme serine protease which has the property of fibrinenhanced conversion of plasminogen to plasmin. Before you are treated with tenecteplase, tell your doctor if you have a blood vessel disorder of the eye, severe liver or kidney disease, high blood pressure, an infection of the lining of your heart also called bacterial endocarditis, a recent history of stomach or urinary bleeding, if you have recently had a baby, or if you have recently had a serious injury or major surgery. Jan 01, 2020 tnkase is a sterile, white to offwhite, lyophilized powder for single intravenous iv bolus administration after reconstitution with sterile water for injection swfi, usp. The pdfpages package makes it easy to insert pages of external pdf. Tnkase tenecteplase dose, indications, adverse effects. When introduced into the systemic circulation at pharmacologic concentration, activase binds to fibrin in a thrombus and converts the entrapped. Retavase fda prescribing information, side effects and uses. It is synthesized using the complementary dna cdna for natural human tissue. Appendix 3 alteplase use in hemodialysis central venous catheters contd 5.
Highlights of prescribing information these highlights do not include all the information needed to use nulojix safely and effectively. It helps your body produce a substance that dissolves unwanted blood clots. Convert word, powerpoint and excel files to and from pdf. Alteplase is a prescription medication used to break up or dissolve blood clots. The angiographic results from timi 10b and the safety data from assent 1, an additional uncontrolled safety study of 3,235 tnkase treated patients, provided the framework to develop a weight tiered tnkase dose regimen.
Asa 320 mg 4 tabs 80 mg chewed stat unless allergic then ecasa 80 mg qd. Dailymed cathflo activase alteplase injection, powder. Singleuse vial lytic thrombolytic cathflo activase alteplase cathflo activase alteplase the only thrombolytic agent fdaapproved for adult and pediatric patients and the standard of care for treatment of thrombotically occluded catheters as assessed by the ability to withdraw blood 1,3,23. They help prevent adverse lv remodeling, delay progression of heart. Nulojix belatacept for injection, for intravenous use initial u. Contraindications cathflo activase should not be administered to patients with known hypersensitivity to alteplase or any component of the. Crationale for use of thrombolysis ardiovascular disease accounts for a large proportion of all deaths in both men and women in the united states. Tenecteplase side effects, dosage, interactions drugs.
Tnkase tenecteplase side effects, images, uses, dosage. Insert the syringe into the stopper on the 50mg vial of activase and inject the contents, directing the stream into the lyophilized cake. Mar 09, 2018 activase is supplied as a sterile, lyophilized powder in 50 mg vials containing vacuum and in 100 mg vials without vacuum. Alteplase belongs to a group of drugs called thrombolytics. Tnkase tenecteplase description tnkase tenecteplase is a tissue plasminogen activator tpa produced by recombinant dna technology using an established mammalian cell line chinese hamster ovary cells. Reconstitute cathflo activase to a final concentration of 1 mgml. Acls drugs, cardioversion, defibrillation and pacing. Solving all your pdf problems in one place and yes, free. Reteplase is a thrombolytic thrombolitik drug that is used to dissolve blood clots. Reteplase is indicated for use in the management of acute myocardial infarction ami in adults for the improvement of ventricular function following ami. Acute myocardial infarction preprinted order sheet. Dec 24, 2019 ndc 5024212001 tenecteplase tnkase 50 mg rx only.
Cathflo activase alteplase for injection is a sterile, white to pale yellow, lyophilized powder for intracatheter instillation for restoration of function to central venous access devices following reconstitution with sterile water for injection, usp. Nov 09, 2018 tenecteplase is a thrombolytic thrombolitik drug, sometimes called a clotbusting drug. With vtex it is even possible to use this package to insert postscript files, in addition to pdf files. The benefits of thrombolytic therapy vs placebo were sustained at 1 year. In this episode i cover when to iv push alteplase for pe and much more. Reconstitute retavase only with the supplied sterile water for injection. Iv alteplase tissue plasminogen activator, ivtpa treatment of ischemic stroke. Tenecteplase versus alteplase for stroke thrombolysis evaluation taste, conceived and led by associate professor parsons, is a large phase iii randomised trial designed to generate practicechanging evidence by applying the advanced imaging treatment selection approach used in his recent positive phase ii trial. Begin by assembling the 50mg vial of activase, the vial of swfi usp, included with the activase package, a 50ml syringe, a largebore needle eg, 18gauge, and alcohol wipes. Appendix alteplase use in hemodialysis central venous. Dobutamine was compatible at concentrations up to 4 mgml but incompatible at a concentration of 12. If resistance is felt at any time, use a gentle pushpull motion to instill the lumen.
Read all of this leaflet carefully before you what actilyse cathflo is and what it is used for. Each 50 mg activase vial 29 million iu is packaged with diluent for reconstitution 50 ml sterile water for injection, usp. It has been used to treat people with fabry disease for over 15 years and is backed by the safety and effectiveness shown in clinical studies. Treatment with actilyse should be initiated as early as possible within 4. Tenecteplase tnk is a novel fibrinspecific thrombolytic agent recently approved for the reduction of mortality associated with acute myocardial infarction ami. Alteplase side effects, uses, dosage, overdose, pregnancy. It produces limited conversion of plasminogen in the absence of fibrin. What are the possible side effects of tenecteplase tnkase. Upload pdfs and embed them straight into your site just like adding images. Inclusion criteria patients who should receive iv alteplase symptoms suggestive of ischemic stroke that are deemed to be disabling, regardless of improvement see. Please be advised hereafter you find the spc for metalyse as approved by ema for the countries of the european union in other areas the wording of the respective prescribing information may differ. Tnkase tenecteplase is indicated for use in the reduction of mortality associated with acute myocardial infarction ami. Step 1 remove the shield assembly from the supplied bd 10 ml syringe with twinpak dual cannula device.
Also, prepare a polyvinyl chloride bag or glass vial along with an infusion set. Remove the protective cap from one end of the transfer device and keeping the vial of swfi upright, insert the piercing pin vertically into the center of the stopper of the vial of swfi. Vanco patient for 5 more days a matter of weighing the risk of infection from the obstructed lumen and increased risk and cost of inserting a new picc vs benefits of using the open lumen for the remainder of therapy. Pdfs will be automatically sized to their natural size and shape or just fill the. Alteplase package insert pdf keyword found websites. Infed iron dextran injection usp is a dark brown, slightly viscous sterile liquid complex of ferric hydroxide and dextran for intravenous or intramuscular use. Each ml contains the equivalent of 50 mg of elemental iron as an iron dextran complex, approximately 0. These dissolve blood clots quickly to help restart blood flow to the heart and helps prevent damage to the heart muscle. Insert pdf file in latex document tex latex stack exchange. Tenecteplase versus alteplase for stroke thrombolysis.
Tenecteplase is a 527 amino acid glycoprotein developed by introducing the following. The most common side effect of activase is bleeding, including gastrointestinal bleeding, genitourinary bleeding, bruising, nosebleed, and bleeding gums. Find patient medical information for alteplase intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Package insert instructions must be followed accordingly. Do not flush medications down the toilet or pour them into drainage unless instructed to do so. Pdf tenecteplase for treatment of acute myocardial infarction. Prescribing and administration guide for intraarterial tenecteplase for the treatment of acute limb ischemia background acute limb ischemia ali, defined as any sudden decrease in, or worsening of limb perfusion causing a. Highlights of prescribing information acute ischemic. Can save pdf pages as jpg, png, bmp, gif, tif image.
Find patient medical information for reteplase intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Open the package containing the transfer device by peeling the paper label off the package. If possible before you receive tenecteplase, tell your doctor if you have a brain tumor or aneurysm, high blood pressure, hemophilia or other bleeding disorder, a history of stroke, or if you have recently had a head injury or surgery on your brain or spinal cord. Follow the dosing and administration guidelines here to treat your acute massive pulmonary embolism ampe patients with activase alteplase. What is the most important information i should know about tenecteplase tnkase.